Episode 41: Can One Dose Cure Addiction? The Promise and Peril of Ibogaine

This week on The Tox Lab, we’re taking a closer look at ibogaine — a plant-derived alkaloid attracting interest as a potential treatment for addiction.

We discuss a study from New Zealand exploring its use in opioid dependence, while also highlighting the serious risks reported in case studies, including severe cardiotoxicity. We then turn to National Poisons Information Service data to examine recent trends in ibogaine use in the UK.

Can the therapeutic potential of ibogaine ever outweigh its dangers? Join us as we unpack the evidence, the risks, and the unanswered questions around this compound.

Hope you enjoy!

Link to the papers we discussed:

https://www.tandfonline.com/doi/10.1080/00952990.2017.1310218?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

https://www.tandfonline.com/doi/full/10.1080/15563650.2024.2447500#:~:text=Our%20cases%20are%20consistent%20with,of%20cardiac%20output%20and%20arrest

https://onlinelibrary.wiley.com/doi/full/10.1002/joa3.12061

https://erowid.org/experiences/exp.php?ID=63089

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