Apr 28, 2025 | 00:22:10
Episode 25: Mitragynine and 7-Hydroxymitragynine – Uncovering Kratom’s Alkaloids
In this week’s episode, we turn our focus to mitragynine and 7-hydroxymitragynine, the primary active components of kratom. We explore what these alkaloids are, how they behave post-mortem, and what we know about their…
In this week’s episode, we turn our focus to mitragynine and 7-hydroxymitragynine, the primary active components of kratom. We explore what these alkaloids are, how they behave post-mortem, and what we know about their stability in biological matrices. We also discuss the evidence around 7-hydroxymitragynine’s role in respiratory depression, and the growing concern around kratom products in the U.S. that contain 7-hydroxymitragynine as their primary compound. Join us as we unpack the complexities surrounding these substances and their implications for toxicologists.
Hope you enjoy!
Links to papers we discussed:
https://academic.oup.com/jat/article-abstract/49/2/122/7934595?redirectedFrom=fulltext
https://pmc.ncbi.nlm.nih.gov/articles/PMC9314834/
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